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"Cow Pock-or-the Wonderful Effects of the New Inoculation!" an 1802 cartoon of English physician Edward Jenner vaccinating patients, who feared it would make them sprout cow-like appendages.
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In a crowded room a physician (Jenner) prepares to vaccinate a young woman sitting in a chair; the scene about them is mayhem as several former patients demonstrate the effects of the vaccine with cows sprouting from various parts of their bodies.

Credit: Courtesy U.S. National Library of Medicine

Widely heralded as the doctor who introduced vaccines, English physician Edward Jenner gave his first inoculation on May, 1796, to a young boy, with material from the cowpox blisters of a milkmaid who had caught cowpox from a cow. Controversial at first among both doctors and the general public, vaccines would help control and eradicate some of the world’s deadliest diseases. Once one of the great epidemic killers, smallpox was declared an eradicated disease by the World Health Organization in 1980.

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